The permeation mechanism of organic cations through a CNG mimic channel
نویسندگان
چکیده
منابع مشابه
On the Structural Basis for Size-selective Permeation of Organic Cations through the Voltage-gated Sodium Channel
Recent evidence indicates that ionic selectivity in voltage-gated Na+ channels is mediated by a small number of residues in P-region segments that link transmembrane elements S5 and S6 in each of four homologous domains denoted I, II, III, and IV. Important determinants for this function appear to be a set of conserved charged residues in the first three homologous domains, Asp(I), Glu(II), and...
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The pe rmea t ion o f monova len t cations th rough the cGMP-gated channel of catfish cone ou te r segments was examined by measur ing permeabi l i ty and conduc tance ratios u n d e r bi ionic condit ions. For monova len t cations presented on the cytoplasmic side of the channel , the permeabi l i ty ratios with respect to extracel lular Na followed the sequence NH4 > K > Li > Rb = Na > Cs whi...
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The permeation of monovalent cations through the cGMP-gated channel of catfish cone outer segments was examined by measuring permeability and conductance ratios under biionic conditions. For monovalent cations presented on the cytoplasmic side of the channel, the permeability ratios with respect to extracellular Na followed the sequence NH4 > K > Li > Rb = Na > Cs while the conductance ratios a...
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Block, permeation, and agonist action of small organic amine compounds were studied in acetylcholine receptor (AChR) channels. Single channel conductances were calculated from fluctuation analysis at the frog neuromuscular junction and measured by patch clamp of cultured rat myotubes. The conductance was depressed by a few millimolar external dimethylammonium, arginine, dimethyldiethanolammoniu...
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The influenza A virus M2 channel (AM2) is crucial in the viral life cycle. Despite many previous experimental and computational studies, the mechanism of the activating process in which proton permeation acidifies the virion to release the viral RNA and core proteins is not well understood. Herein the AM2 proton permeation process has been systematically characterized using multiscale computer ...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2018
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1006295